HDMe Time
This study was carried out to investigate whether minute quantities of maternal drugs ingested over an extended period of time by a breast-feeding infant can alter the activity pattern of the infant's hepatic drug metabolizing enzyme (HDME). The HDME activity patterns of 12 breast-fed infants whose mothers were not on drug therapy were compared with those of 11 infants whose mothers had been taking 30 micrograms levo-norgesterel daily for 90 to 195 days (oral contraceptives group) and of 10 infants whose mothers had been taking ethambutol and isoniazid daily since pregnancy (tuberculosis group). As 6 beta hydroxycortisol in urine is considered to be a good and acceptable reflector of HDME activity, it was estimated from the infants' urine using enzyme-linked immunosorbent assay (ELISA) technique. A comparison of the patterns between 90 days of age and 195 days of age of the infants in the control group and the two study groups indicated an increase from 36.6 ng/mL to 58.4 ng/mL at 195 days in the control group. An initial decrease from 36.6 ng/mL to 26.2 ng/mL was noted with commencement of maternal levo-norgesterel therapy, followed by a slow and steady rise to 47.8 ng/mL at 195 days of age, with a shift in the peak from 120 to 135 days of infants age in the oral contraceptive group. A suppressed pattern with decreased levels of 6 beta hydroxycortisol ranging from 19.3 ng/mL to 26.5 ng/mL at 195 days was found in the tuberculosis group. The data were analyzed by two-way analysis of variance (ANOVA) coupled with Duncan's Multiple range test. Both treatment group showed significant differences from the control group at the 0.050 level. The HDME plays an important role in determining the final outcome of any drug in humans, as it controls the metabolism of drugs. Hence, alterations in its activity caused by the transfer of maternal drugs over a prolonged period of time could pose a serious problem to nurslings when they require drugs for their own benefit.
HDMe Time
Heracleum dissectum Ledeb. has long been used as a wild edible vegetable by local people in China. The purpose of this study is to investigate the antidiabetic potential of aerial part of H. dissectum methanol extract (HdME) and the chemical constituents. Ten compounds including eight coumarins were isolated and four of them were found from H. dissectum for the first time. HdME potently inhibited the elevation of plasma glucose after its oral administration to glucose-loaded mice, and its petroleum ether (PE) fraction exerted the greatest inhibitory activities. Meanwhile, HdME (125 and 250mg/kg) also significantly decreased the blood glucose level in STZ-induced diabetic mice, but had no effect in normoglycemic mice. Additionally, HdME showed weak inhibitory effects on α-glucosidase activity and DPPH free radicals scavenging. In conclusion, HdME has antidiabetic action and PE fraction is the active part where coumarins possibly play an important role in antidiabetic activity.
"The risk of thermal shock is reduced, and at the same time the higher viscosity and greater lubricity of HDME 50 means it offers greater protection. It's also less volatile, which, of particular interest for the tankers, means it's a much safer product to use in a large boiler."
Participants will be encouraged to spend at least a minimum amount of time each week dedicated to course reading, attendance in the 90-minute live web session, and practice activities to ensure knowledge capture.
ExxonMobil Premium HDME 50 fuel should always be stored in a heated tank. Prior to transfer, it should be heated to enable pumping. ExxonMobil Premium HDME 50 fuel will have a cleaning effect on the storage tank, and is likely to carry any existing fuel oil residues/sludge that are present in the tank, having built up over time. These residues may be picked up in filters further down the fuel treatment process. This is more likely during the initial use of ExxonMobil Premium HDME 50 fuel.
Stripping voltammetry means, that the analyte is ccumulated in a first step at the surface of the working electrode. To do so an appropriate accumulation potential is applied to the electrode for a defined time intervall (accumulation time). The analyte is then stripped back into the solution in a second step. The enrichment of the analyte effects the high sensitivity. The most sensitive methods are anodic, cathodic and adsorptive stripping voltammetry, combined with the differential pulse technique. The detection limits using stripping voltammetry depends on the analyte, the best detection limits are about 0,01 μg/l (ppb).
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